On the Gaussian Many-to-One X Channel

In this paper, the Gaussian many-to-one X channel, which is a special case of general multiuser X channel, is studied. In the Gaussian many-to-one X channel, communication links exist between all transmitters and one of the receivers, along with a communication link between each transmitter and its corresponding receiver. As per the X channel assumption, transmission of messages is allowed on all the links of the channel. This communication model is different from the corresponding many-to-one interference channel (IC). Transmission strategies which involve using Gaussian codebooks and treating interference from a subset of transmitters as noise are formulated for the above channel. Sum-rate is used as the criterion of optimality for evaluating the strategies. Initially, a $3 \times 3$ many-to-one X channel is considered and three transmission strategies are analyzed. The first two strategies are shown to achieve sum-rate capacity under certain channel conditions. For the third strategy, a sum-rate outer bound is derived and the gap between the outer bound and the achieved rate is characterized. These results are later extended to the $K \times K$ case. Next, a region in which the many-to-one X channel can be operated as a many-to-one IC without loss of sum-rate is identified. Further, in the above region, it is shown that using Gaussian codebooks and treating interference as noise achieves a rate point that is within $K/2 -1$ bits from the sum-rate capacity. Subsequently, some implications of the above results to the Gaussian many-to-one IC are discussed. Transmission strategies for the many-to-one IC are formulated and channel conditions under which the strategies achieve sum-rate capacity are obtained. A region where the sum-rate capacity can be characterized to within $K/2-1$ bits is also identified.Comment: Submitted to IEEE Transactions on Information Theory; Revised and updated version of the original draf

ASSESSMENT OF ANNULAR FLOW BOILING IN THE CONTEXT OF COMPUTATIONAL FLUID DYNAMICS (CFD) SIMULATIONS, EXPERIMENTS, AND EXISTING CORRELATIONS

The main objective of the current work is to achieve a better understanding – through modeling and simulation/programming activities – of annular flow-boiling and its applications based on a synthesis of Computational Fluid Dynamics (CFD) simulations, existing correlations, and experiments. A unique and rigorous 2-D CFD simulations technique was developed for annular flow-boiling to propose a correlation for convective component of Heat Transfer Coefficient (HTC) – defined here as flow-boiling in the absence of nucleation. To provide a context for the correlation structure of convective component of HTC, flow-physics details of annular flow-boiling and correlation structure (based on fundamental considerations) for HTC have also been discussed. Further, other existing correlations for Nusselt number, void-fraction, flow-regime transition, and pressure-drop have been used to develop a general but first order engineering estimates-methodology for design of annular flow-boilers and flow-condensers. The first order estimates-methodology, thus developed for annular flow-boiler operations, was used to: (i) make a priori estimates of flow predictions towards choosing suitable instrumentations for the design of a particular test-section and associated flow-loop needed for a new high heat-flux flow-boiling experiments involving water as a working fluid), and (ii) define a range of experimental operating conditions – for a low heat-flux test-section and flow-loop (involving FC-72 as working fluid) facility from which experimental data needed to be obtained to throw light on the flow-physics being modeled by the CFD code. Furthermore, preliminary results from a different low heat-flux experiments are briefly discussed here and then compared with rigorous CFD simulations to achieve better understanding of the flow-physics

Towards a new approach for enterprise integration : the semantic modeling approach

Manufacturing today has become a matter of the effective and efficient application of information technology and knowledge engineering. Manufacturing firms’ success depends to a great extent on information technology, which emphasizes the integration of the information systems used by a manufacturing enterprise. This integration is also called enterprise application integration (here the term application means information systems or software systems). The methodology for enterprise application integration, in particular enterprise application integration automation, has been studied for at least a decade; however, no satisfactory solution has been found. Enterprise application integration is becoming even more difficult due to the explosive growth of various information systems as a result of ever increasing competition in the software market. This thesis aims to provide a novel solution to enterprise application integration. The semantic data model concept that evolved in database technology is revisited and applied to enterprise application integration. This has led to two novel ideas developed in this thesis. First, an ontology of an enterprise with five levels (following the data abstraction: generalization/specialization) is proposed and represented using unified modeling language. Second, both the ontology for the enterprise functions and the ontology for the enterprise applications are modeled to allow automatic processing of information back and forth between these two domains. The approach with these novel ideas is called the enterprise semantic model approach. The thesis presents a detailed description of the enterprise semantic model approach, including the fundamental rationale behind the enterprise semantic model, the ontology of enterprises with levels, and a systematic way towards the construction of a particular enterprise semantic model for a company. A case study is provided to illustrate how the approach works and to show the high potential of solving the existing problems within enterprise application integration

Locally compact abelian groups with symplectic self-duality

Is every locally compact abelian group which admits a symplectic self-duality isomorphic to the product of a locally compact abelian group and its Pontryagin dual? Several sufficient conditions, covering all the typical applications are found. Counterexamples are produced by studying a seemingly unrelated question about the structure of maximal isotropic subgroups of finite abelian groups with symplectic self-duality (where the original question always has an affirmative answer).Comment: 23 page

Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.The malaria parasite Plasmodium obligatorily infects and replicates inside hepatocytes surrounded by a parasitophorous vacuole membrane (PVM), which is decorated by the host-cell derived autophagy protein LC3. We have previously shown that the parasite-derived, PVM-resident protein UIS3 sequesters LC3 to avoid parasite elimination by autophagy from hepatocytes. Here we show that a small molecule capable of disrupting this interaction triggers parasite elimination in a host cell autophagy-dependent manner. Molecular docking analysis of more than 20 million compounds combined with a phenotypic screen identified one molecule, C4 (4-{[4-(4-{5-[3-(trifluoromethyl) phenyl]-1,2,4-oxadiazol-3-yl}benzyl)piperazino]carbonyl}benzonitrile), capable of impairing infection. Using biophysical assays, we established that this impairment is due to the ability of C4 to disrupt UIS3–LC3 interaction, thus inhibiting the parasite’s ability to evade the host autophagy response. C4 impacts infection in autophagy-sufficient cells without harming the normal autophagy pathway of the host cell. This study, by revealing the disruption of a critical host–parasite interaction without affecting the host’s normal function, uncovers an efficient anti-malarial strategy to prevent this deadly disease.This work was supported by grants from Institut Mérieux (MRG_20052016 to M.M.M). S.S. and A.F.C. were recipients of Fundação para a Ciência e Tecnologia fellowships SFRH/BPD/116451/2016 and SFRH/BPD/112009/2015, respectively. H.R. and V.S. were supported by core funds from NCBS-TIFR. A.L. was supported by Sanofi-Institut Pasteur 2018 Prize to M.M.M.info:eu-repo/semantics/publishedVersio

Phylogenetic Characterization of Six Full-Length HIV-1 Subtype C Molecular Clones from Three Patients: Identification of Rare Subtype C Strains Containing Two NF-κB Motifs in the Long Terminal Repeat

Molecular surveillance is the backbone of HIV-1 vaccinology. Full-length HIV-1 sequences are useful tools that can provide a better understanding of the epidemiology in a given region. A limited number of full-length HIV-1 sequences are available from India, where >95% of the HIV infections are due to HIV-1 subtype C (HIV-1C), which is distinct from the prototype African HIV-1C. In this study, we sequenced six full-length clones isolated from three patients. Extensive phylogenetic analyses of the full-length viral sequences using bioinformatic tools identified a separate cluster of Indian strains, thus confirming the distinct phylogenetic identity of the Indian HIV-1C. Notably, the long terminal repeat (LTR) of two of the six molecular clones contained only two NF-κB binding sites. The sequences also displayed features characteristic of HIV-1C including a Tat dicysteine motif, a shortened Rev open reading frame, and a predicted CCR5 coreceptor tropism for gp120 of three of the proviral sequences

Decadal variations in NDVI and food production in India

In this study we use long-term satellite, climate, and crop observations to document the spatial distribution of the recent stagnation in food grain production affecting the water-limited tropics (WLT), a region where 1.5 billion people live and depend on local agriculture that is constrained by chronic water shortages. Overall, our analysis shows that the recent stagnation in food production is corroborated by satellite data. The growth rate annually integrated vegetation greenness, a measure of crop growth, has declined significantly (p < 0.10) in 23% of the WLT cropland area during the last decade, while statistically significant increases in the growth rates account for less than 2%. In most countries, the decade-long declines appear to be primarily due to unsustainable crop management practices rather than climate alone. One quarter of the statistically significant declines are observed in India, which with the world’s largest population of food-insecure people and largest WLT croplands, is a leading example of the observed declines. Here we show geographically matching patterns of enhanced crop production and irrigation expansion with groundwater that have leveled off in the past decade. We estimate that, in the absence of irrigation, the enhancement in dry-season food grain production in India, during 1982–2002, would have required an increase in annual rainfall of at least 30% over almost half of the cropland area. This suggests that the past expansion of use of irrigation has not been sustainable. We expect that improved surface and groundwater management practices will be required to reverse the recent food grain production declines

Distributed Sensing, Computing, Communication, and Control Fabric: A Unified Service-Level Architecture for 6G

With the advent of the multimodal immersive communication system, people can interact with each other using multiple devices for sensing, communication and/or control either onsite or remotely. As a breakthrough concept, a distributed sensing, computing, communications, and control (DS3C) fabric is introduced in this paper for provisioning 6G services in multi-tenant environments in a unified manner. The DS3C fabric can be further enhanced by natively incorporating intelligent algorithms for network automation and managing networking, computing, and sensing resources efficiently to serve vertical use cases with extreme and/or conflicting requirements. As such, the paper proposes a novel end-to-end 6G system architecture with enhanced intelligence spanning across different network, computing, and business domains, identifies vertical use cases and presents an overview of the relevant standardization and pre-standardization landscape

Guest Editorial Special Issue on Green Internet of Things: Challenges and Future Opportunities - Part i

[No abstract available

Guest Editorial: Special issue on green internet of things: Challenges and future opportunities - Part II

[No abstract available